what is the national institute of aging

In addition to building a portfolio of novel therapeutics for a diverse set of therapeutic targets, the branch supports the development of translational infrastructure that operates under open-source, open-science principles to increase research rigor, reproducibility and translatability. Endocrinology supports basic research into the causes and effects of age-related changes in the endocrine system, and on aging-dependent changes in cellular responses to endocrine factors. Global Aging Find information on research into global trends in … As an author of more than 250 research papers, Dr. Hodes is an influential scientist in and contributor to the field of immunology. NIA plays a critical role in developing the first goal of the plan, which is to Effectively Treat or Prevent Alzheimer’s by 2025. The goal is to promote exercise and physical activity nationwide for people 50 and older. NIA’s extramural program funds research and training at universities, hospitals, medical centers and other public and private organizations nationwide. Researchers study the mechanism involved in DNA repair of oxidative lesions; and in base excision repair, including the function of individual DNA repair proteins and their protein interactions. National Institute on Aging (NIA) Scientific Director: Luigi Ferrucci, M.D., Ph.D. LMG has found a signaling pathway from nuclear damage to mitochondrial dysfunction, which seems to be defective in some DNA repair defective disorders including Alzheimer’s disease, and intervention with nicotinamide adenine dinucleotide supplementation has beneficial effects. PSP supports research and data infrastructure development projects on how demographic, social, economic, institutional, geographic and other factors at the population level influence health and mortality at older ages. NIH, represented by NIA, participates in the federal Advisory Council on Alzheimer’s Research, Care, and Services. Alzheimer’s disease research implementation milestones, Alzheimer's & Dementia Outreach, Recruitment & Engagement Resources (ADORE), Together We Make the Difference: National Strategy for Recruitment and Participation in Alzheimer’s and Related Dementias Clinical Research. NIA supports a variety of longitudinal studies (most notably the population-representative Health and Retirement Study), harmonization projects, archives, and repositories to facilitate research on aging in the behavioral and social sciences. LMBI also collaborates with Baltimore Longitudinal Study of Aging researchers to enable direct application of molecular parameters to the human condition. Research in geriatrics is uncovering new ways to combat frailty and improve function with age. Our programs have been adjusted to meet the recommendations from the CDC and DPH, focusing on the health and safety of both our clients and staff. He is a diplomate of the American Board of Internal Medicine, a member of The Dana Alliance for Brain Initiatives, a fellow of the American Association for the Advancement of Science, and a member of the National Academy of Medicine at the National Academies of Sciences, Engineering, and Medicine. LNS seeks to understand the cellular and molecular mechanisms of neural plasticity during aging and to develop novel interventions for the prevention and treatment of neurodegenerative conditions such as Alzheimer's, Parkinson's and Huntington's diseases, as well as stroke. National Institute on Aging - NIH, Bethesda, Maryland. from Harvard Medical School. Research using a diverse set of analytical approaches, including life cycle, comparative, geographic distribution, rural/urban, cohort and multi-level). April 23, 1975 — First meeting of the National Advisory Council on Aging is held. Laboratory of Clinical Investigation (LCI) NIH, with NIA leadership, leads U.S. participation in a new international effort to address Alzheimer’s disease research and care. Congress created NACA to advise, consult with and make recommendations to the HHS Secretary and Assistant Secretary for Health, and the NIH and NIA directors. Connect with NIA Laboratory of Neurosciences (LNS) Metabolic Regulation supports research on nutrition and metabolism in relation to aging including age-related changes in intermediary metabolism, mitochondrial [dys]function, and mechanisms by which caloric restriction, circadian rhythms, free radicals and oxidative stress affect metabolism and healthy aging. The focus was on how chronic diseases – specifically cancer, HIV/AIDS and diabetes – affect biological aging. In the elderly living in the community, 30%–50% of falls are due to environmental causes (eg, poor lighting, slippery floors, and uneven surfaces) The laboratory takes a multi-modality and multi-disciplinary approach that is applied in population-based cohorts developed by LEPS scientists in collaboration with other intramural and with extramural investigators. DAB chairs the Trans-NIH Geroscience Interest Group (GSIG) that includes representation from 20 NIH Institutes and Centers. The National Institute on Aging (NIA) is one of 27 Institutes and Centers of the National Institutes of Health (NIH), a component of the U.S. Department of Health and Human Services. ; 2 Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA. Data Resources for Behavioral and Social Research on Aging. 1992 — NIA and the University of Michigan begin the Health and Retirement Study, which follows more than 20,000 people at 2-year intervals, providing data from pre-retirement to advanced age to enable multidisciplinary study of the causes and course of retirement. Basic Science of Alzheimer’s Disease supports examination of the role molecular, cellular, synaptic and circuitry mechanisms, inflammation, proteinopathy and cerebrovasculature in the etiology and pathobiology of Alzheimer’s disease, other dementias of aging, and neurodegenerative diseases associated with unconventional agents. SBR conducts initial peer review of specific research applications assigned to the NIA. 2003 — NIA and the American Federation for Aging Research — in collaboration with the John A. Hartford Foundation, Atlantic Philanthropies and Staff Foundation — establish a public-private partnership to support clinically trained junior faculty to pursue careers in aging research. 2011 — NIA launches the Go4Life campaign with public and private partners from a variety of aging, fitness and provider organizations. Laboratory of Epidemiology and Population Sciences (LEPS) The National Institute on Aging (NIA) is a division of the U.S. National Institutes of Health (NIH), located in Bethesda, Maryland. 2004 — NIA launches the Longevity Consortium, a network of investigators from several large-scale human cohort studies working in collaboration with individual basic biological aging researchers to facilitate the discovery, confirmation and understanding of genetic determinants of healthy human longevity. The branch supports all stages of clinical development for pharmacologic and non-pharmacologic interventions and combination therapies, as well as research on methods development and training for innovative trial design. NIA, with other institutes and the private sector, cosponsors the Alzheimer’s Disease-Related Dementias: Research Challenges and Opportunities Summit, led by the National Institute of Neurological Disorders and Stroke (NINDS). Basic biologic research is examining genetic and other factors influencing aging, how they affect longevity and the development of age-related diseases. A full 80 percent of falls happen in the bathroom, according to NewsUSA, quoting a National Institute on Aging statistic. Since 1974, the National Institute on Aging (NIA) mission has been to improve the health and well-being of older Americans through biomedical, social and behavioral research. A graduate of Yale University, Dr. Hodes received his M.D. The Baltimore Longitudinal Study of Aging is America's longest-running scientific study of human aging. A wide variety of in vitro and in vivo models are employed to approach these issues. Research emphases include multifactorial geriatric syndromes such as falls, frailty, and various types of disability; effects of comorbidity and polypharmacy; effects of age-related changes on clinical or functional disease outcomes or treatment responses; effects of physical activity on disease and disability in older persons; and the elucidation, diagnosis, and treatment of previously unappreciated pathologic changes in old age (e.g., sarcopenia, vascular stiffening, diastolic dysfunction). Clinical Gerontology focuses on clinically related research on aging changes over the lifespan. LBN conducts basic and clinical research on individual differences in cognition, personality and affect; investigates the cellular, neural systems and genetic contributions to variation between individuals in animal models and humans; examines predictors and modifiers of age-related neurodegenerative diseases and age-associated changes in behavior, predispositions and brain-behavior associations; identifies early markers of Alzheimer’s disease and cognitive decline; examines factors that promote the maintenance of cognitive health; and develops and validates blood-based and imaging biomarkers of age-related neurodegeneration to inform diagnosis and the testing of potential therapeutic interventions. A consortium of three upstate New York universities has received a five-year, $1.5 million grant from the National Institute on Aging (NIA) to fund the Center for Aging and Policy Studies (CAPS), headquartered at Syracuse University. Mission. This includes research on mechanisms of behavior change and behavioral interventions, cognitive and emotional functioning, molecular and behavior genetics, sociogenomics, technology and human factors, family and interpersonal relationships, and integrative biobehavioral research on the mechanistic pathways linking social and behavioral factors to health in mid-life and older age. (PDF, 11.4M) NIA, in conjunction with other federal agencies and private companies and organizations through the Foundation for the National Institutes of Health, leads the Alzheimer's Disease Neuroimaging Initiative. The Alzheimer's Association's Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease. 2007 — U.S. Secretary of State Condoleezza Rice sponsors the Summit on Global Aging in collaboration with NIA to call attention to challenges and opportunities worldwide from population aging. DGCG comprises three major research areas, divided into three division branches — Geriatrics, Clinical Gerontology, and Clinical Trials. Genetics supports studies to identify and characterize molecular mechanisms affecting longevity and healthy aging in the areas of genome stability, telomere biology, chromatin, epigenetic changes and progeroid syndromes. LMBI programs have a strong translational component with studies aimed at improving vaccine efficacy in the elderly and examining the molecular and cellular basis of tumor metastasis. NIA leads the AMP Alzheimer’s disease component. Research on disorders of the sensory systems, such as presbycusis or pain, are highlighted. The mission of the National Institute of Nursing Research (NINR) is to promote and improve the health of individuals, families, communities, and populations. This branch supports the full spectrum of drug discovery and preclinical drug development from target discovery and validation through securing Investigational New Drug status for small molecules and biologics aimed at prevention, treatment and management of individuals with or at-risk for cognitive decline, Alzheimer's disease and related dementias. BSR is committed to advancing high-caliber science in a variety of disciplines, including demography, lifespan development, psychology, behavioral medicine, behavioral economics, sociology, interpersonal relationships, health services research, behavioral genetics, and social epidemiology to promote the health and wellbeing of persons living with AD/ADRD and their caregivers. The unifying theme of LMBI's research program is to uncover molecular mechanisms that are pertinent to understanding and ameliorating age-associated disabilities and diseases, with emphasis on changes in the immune system. Looking for advice about healthy aging? Translational Gerontology Branch (TGB) There is a strong emphasis on life course research, including early life influences on later life outcomes as well as research on behavioral and social processes in midlife that play a causal role in shaping trajectories of aging. May 31, 1974 — Public Law 93-296 authorizes the establishment of a National Institute on Aging and mandates the Institute develop a national comprehensive plan to coordinate the U.S. Department of Health, Education, and Welfare (succeeded by the Department of Health and Human Services) involvement in aging research. Aging and Your Eyes. 100-607 establishes the Geriatric Research and Training Centers, renamed the Claude D. Pepper Older American Independence Centers in 1990 and charged with conducting research on diseases that threaten independent living. NIA is the primary Federal agency supporting and conducting Alzheimer's disease research. 2001 — In a unique private-public partnership, NIA joins the Osteoarthritis Initiative to bring together resources and commitment to the search for biological markers of osteoarthritis. The Trans-NIH Geroscience Interest Group (GSIG) hosts the Advances in Geroscience: Impacts on Healthspan and Chronic Disease Summit. Shingles only made her feel sick for a few days. Laboratory of Genetics and Genomics (LGG) SRB also manages the review of many research project applications, primarily those responding to NIA’s Requests for Applications. Research on dementias of old age — in particular Alzheimer's disease — is one of the division's highest priorities. Get information on applying for funding from NIA. The branch supports research that is highly interdisciplinary, linking methods and approaches from psychology with those of economics, anthropology, neuroscience and genetics, including studies conducted in wild and captive animal models. 1996 — NIA introduces Exercise: A Guide from the National Institute on Aging, providing encouragement and evidence-based guidance specifically for older adults. Laboratory of Cardiovascular Science (LCS) Researchers investigate how accumulation of DNA damage with aging leads to senescence, mitochondrial dysfunction and age-associated disease. LCI investigators hope to uncover ways to manage and/or circumvent the pathological alterations so that the health of the elderly stays stable. NIA leads the formation of the Trans-NIH GeroScience Interest Group. The areas of most intense investigation within LCI are pancreatic islet morphology and changes therein with obesity and aging; molecular and cellular changes with osteoarthritis; metabolic causes of neurodegeneration; alterations in drug metabolism with age; and development of plant-based compounds as treatments for metabolic conditions. Dr. Phelps discusses the challenges facing AD researchers and how the NIA is working to overcome them. NIA launches the International Alzheimer’s Disease Research Portfolio. Collaboration with other NIA center programs is encouraged to enhance interdisciplinary research, Behavioral and Social Research on Alzheimer’s Disease. Research emphases include interventions to prevent or treat “geriatric syndromes,” disability, and complications of comorbidity or polypharmacy; trials to detect age- or comorbidity-related differences in responses to interventions against conditions found in middle age and old age; interventions for problems associated with menopause and other mid- and late-life changes; interventions that may affect rates of progression of age-related declines in function in early and mid-life; and interventions with protective effects against multiple age-related conditions, including intervention studies on the effects of androgens in older men. The NCOA’s social impact goals for 2020 focus on health, economic security, and public policy initiatives to protect Social Security, Medicare, Medicaid, and the Older Americans Act. The Sensory Processes program supports studies on neural mechanisms of age- and/or disease-related alterations in visual, auditory, somatosensory, vestibular and chemosensory functions. Neurobiology of Aging and Neurodegeneration. National Institute on Aging Exercise and Physical Activity: Getting Fit for Life “My wife, Miki, and I have heart problems. GSIG aims to accelerate and coordinate efforts to promote further discoveries on the role of aging processes in the development of chronic diseases and disabilities, with the goal of resolving health problems among our increasingly older population. Studies of molecular, structural and dynamic brain changes, including research on adaptation or plasticity, resilience, and reserve are of particular interest, as well as interventions to maintain or gain function in older age. En español Send us your comments. Real World Health…more. Common mechanisms of interest include inflammation, metabolic dysregulation, increase in visceral fat and decrease in muscle mass, elevated blood pressure, and atherosclerosis. The Genetics of Alzheimer's disease Portfolio aimed at discovery of therapeutic targets for AD by identification of regions in the genome conferring risk or protection and associated molecular pathways with clear link to the etiology of disease. It also supports biological resource facilities that provide aged animals and banked tissues for use in aging research. Through our work, our mission is to enhance successful ageing across the life course and to make Canada the best place to grow up and grow old. Dr. Hodes' research laboratory in the National Cancer Institute focuses on the cellular and molecular mechanisms that regulate the immune response. DAB-supported research includes work with isolated or cultured cells, organoids, laboratory animals, wild populations and human subjects. The portfolio includes genome analysis by machine learning and functional genomics to delineate causal genetic variants and related biological mechanisms. 1997 — The Resource Centers for Minority Aging Research are funded to investigate the variability of health differences experienced across racial and ethnic groups, as well as the mentoring of new scholars in health disparities research. Six of the members are leaders from the general public in the fields of public policy, law, health policy, economics and management. Organized into five branches, this division fosters and supports extramural and collaborative research and training to further understanding of neural and behavioral processes and of neurodegenerative diseases associated with the brain aging. Prevention and treatment trials for age-related cognitive decline also are emphasized. This may include direct measurements of morbidity levels in general populations and race/ethnic subpopulations; and identification of potential risk and protective factors through longitudinal studies using biospecimens (blood, cerebrospinal fluid, CNS tissues), neuroimaging, and medical history data to better understand the etiology of MCI/AD/ADRD. NIA scientists and other experts review this content to ensure it is accurate and up to date. IDEAL is a sub-study of the Baltimore function in late life to prevent disease and disability in a small but growing segment of the aging population. As part of our series on Alzheimer’s Disease, Real World Health Care spoke with Creighton Phelps, Ph.D., acting director, Division of Neuroscience, National Institute on Aging, National Institutes of Health. 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